Drug interactions
Celecoxib + Tenecteplase
Severity: Moderate
Celecoxib and Tenecteplase: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tenecteplase is a fibrinolytic that markedly increases bleeding risk, and celecoxib can contribute through mucosal injury and some platelet effects. Concurrent use may raise the chance of gastrointestinal or other bleeding.
What this interaction means in plain words
Celecoxib and Tenecteplase can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Celecoxib belongs to Musculoskeletal; Tenecteplase belongs to Cardiovascular.
Why it happens
Additive effects on haemostasis from pharmacologic fibrinolysis and NSAID-related mucosal and platelet effects.
What to do
Monitor for bleeding and haemoglobin changes after thrombolysis in patients taking celecoxib. Hold the NSAID during the acute phase if possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Other interactions of Tenecteplase
- Alteplase + Tenecteplase Contraindicated
- Acetylsalicylic acid + Tenecteplase Major
- Apixaban + Tenecteplase Major
- Argatroban + Tenecteplase Major
- Dabigatran etexilate + Tenecteplase Major
- Dalteparin + Tenecteplase Major
Frequently asked questions
Can I take Celecoxib with Tenecteplase?
MediHelp rates the interaction as moderate. Celecoxib and Tenecteplase can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tenecteplase is a fibrinolytic that markedly increases bleeding risk, and celecoxib can contribute through mucosal injury and some platelet effects. Concurrent use may raise the chance of gastrointestinal or other bleeding.
How serious is the interaction between Celecoxib and Tenecteplase?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and haemoglobin changes after thrombolysis in patients taking celecoxib. Hold the NSAID during the acute phase if possible.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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