Drug interactions
Celecoxib + Timolol
Severity: Minor
Celecoxib and Timolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic NSAID use can blunt the blood pressure lowering effect of beta-blockers. Timolol is partly metabolized by CYP2D6, but the weak inhibition by celecoxib is unlikely to matter much. Interaction is relevant mainly for oral timolol, with limited effect from ophthalmic use.
What this interaction means in plain words
Celecoxib and Timolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Celecoxib belongs to Musculoskeletal; Timolol belongs to Cardiovascular.
Why it happens
NSAID-related prostaglandin inhibition causes sodium retention and opposes beta-blocker effect, with minor CYP2D6 inhibition.
What to do
Monitor blood pressure and heart rate if oral timolol is used with prolonged celecoxib therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Other interactions of Timolol
- Acebutolol + Timolol Major
- Aldesleukin + Timolol Major
- Amifostine + Timolol Major
- Amiodarone + Timolol Major
- Arformoterol + Timolol Major
- Atenolol-chlorthalidone + Timolol Major
Frequently asked questions
Can I take Celecoxib with Timolol?
MediHelp rates the interaction as minor. Celecoxib and Timolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Systemic NSAID use can blunt the blood pressure lowering effect of beta-blockers. Timolol is partly metabolized by CYP2D6, but the weak inhibition by celecoxib is unlikely to matter much. Interaction is relevant mainly for oral timolol, with limited effect from ophthalmic use.
How serious is the interaction between Celecoxib and Timolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate if oral timolol is used with prolonged celecoxib therapy.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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