Drug interactions
Celecoxib + Tolterodine
Severity: Minor
Celecoxib and Tolterodine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Celecoxib is a weak CYP2D6 inhibitor and may slightly raise tolterodine exposure. Clinical significance is expected to be minimal.
What this interaction means in plain words
Celecoxib and Tolterodine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Celecoxib belongs to Musculoskeletal; Tolterodine belongs to Genitourinary.
Why it happens
Weak CYP2D6 inhibition by celecoxib reduces tolterodine metabolism.
What to do
No dose adjustment is usually needed. Be aware of anticholinergic effects if symptoms develop.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tolterodine
Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Frequently asked questions
Can I take Celecoxib with Tolterodine?
MediHelp rates the interaction as minor. Celecoxib and Tolterodine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Celecoxib is a weak CYP2D6 inhibitor and may slightly raise tolterodine exposure. Clinical significance is expected to be minimal.
How serious is the interaction between Celecoxib and Tolterodine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually needed. Be aware of anticholinergic effects if symptoms develop.
What other medicines interact with Tolterodine?
MediHelp also lists interactions of Tolterodine with, for example, Clarithromycin, Clozapine, Cobicistat. The full list is on the Tolterodine page.
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