Drug interactions
Celecoxib + Tolvaptan
Severity: Minor
Celecoxib and Tolvaptan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tolvaptan does not clearly raise potassium, and there is no established interaction with celecoxib. NSAIDs may worsen renal function in volume-depleted patients, which could matter during aquaresis.
What this interaction means in plain words
Celecoxib and Tolvaptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Celecoxib belongs to Musculoskeletal; Tolvaptan belongs to Endocrine.
Why it happens
No established pharmacokinetic or pharmacodynamic mechanism; theoretical renal effects only.
What to do
Monitor serum sodium and renal function as for routine tolvaptan therapy and maintain hydration.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Other interactions of Tolvaptan
- Atazanavir + Tolvaptan Contraindicated
- Ceritinib + Tolvaptan Contraindicated
- Cobicistat + Tolvaptan Contraindicated
- Conivaptan + Tolvaptan Contraindicated
- Darunavir + Tolvaptan Contraindicated
- Idelalisib + Tolvaptan Contraindicated
Frequently asked questions
Can I take Celecoxib with Tolvaptan?
MediHelp rates the interaction as minor. Celecoxib and Tolvaptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tolvaptan does not clearly raise potassium, and there is no established interaction with celecoxib. NSAIDs may worsen renal function in volume-depleted patients, which could matter during aquaresis.
How serious is the interaction between Celecoxib and Tolvaptan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum sodium and renal function as for routine tolvaptan therapy and maintain hydration.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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