Drug interactions
Celecoxib + Trandolapril
Severity: Moderate
Celecoxib and Trandolapril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Celecoxib can weaken the antihypertensive effect of trandolapril. In older, dehydrated or renally impaired patients, the combination may cause acute kidney injury and hyperkalemia.
What this interaction means in plain words
Celecoxib and Trandolapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Celecoxib belongs to Musculoskeletal; Trandolapril belongs to Cardiovascular.
Why it happens
Inhibition of vasodilatory renal prostaglandin synthesis by the NSAID opposes ACE inhibitor effects and reduces glomerular perfusion.
What to do
Monitor blood pressure, serum creatinine and potassium after initiation and with dose changes, and maintain hydration. Use the lowest effective NSAID dose for the shortest time or choose an alternative analgesic in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Other interactions of Trandolapril
- Aliskiren + Trandolapril Contraindicated
- Protein a column + Trandolapril Contraindicated
- Sacubitril / valsartan + Trandolapril Contraindicated
- Sacubitril-valsartan + Trandolapril Contraindicated
- Aldesleukin + Trandolapril Major
- Amifostine + Trandolapril Major
Frequently asked questions
Can I take Celecoxib with Trandolapril?
MediHelp rates the interaction as moderate. Celecoxib and Trandolapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Celecoxib can weaken the antihypertensive effect of trandolapril. In older, dehydrated or renally impaired patients, the combination may cause acute kidney injury and hyperkalemia.
How serious is the interaction between Celecoxib and Trandolapril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum creatinine and potassium after initiation and with dose changes, and maintain hydration. Use the lowest effective NSAID dose for the shortest time or choose an alternative analgesic in high-risk patients.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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