Drug interactions
Celecoxib + Triamterene
Severity: Major
Celecoxib and Triamterene: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Together these drugs increase the risk of hyperkalemia and acute kidney injury; NSAIDs with triamterene have been associated with reversible renal failure. Risk is highest in older patients and those with renal impairment.
What this interaction means in plain words
Celecoxib and Triamterene can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Celecoxib belongs to Musculoskeletal; Triamterene belongs to Cardiovascular.
Why it happens
NSAIDs reduce renal prostaglandin synthesis, renal perfusion and aldosterone release while triamterene blocks potassium excretion.
What to do
Avoid the combination where possible. If used, monitor serum potassium and creatinine closely and ensure adequate hydration.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Other interactions of Triamterene
- Amiloride + Triamterene Contraindicated
- Eplerenone + Triamterene Contraindicated
- Potassium citrate / citric acid + Triamterene Contraindicated
- Potassium citrate + Triamterene Contraindicated
- Spironolactone + Triamterene Contraindicated
- Aceclofenac + Triamterene Major
Frequently asked questions
Can I take Celecoxib with Triamterene?
MediHelp rates the interaction as major. Celecoxib and Triamterene can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Together these drugs increase the risk of hyperkalemia and acute kidney injury; NSAIDs with triamterene have been associated with reversible renal failure. Risk is highest in older patients and those with renal impairment.
How serious is the interaction between Celecoxib and Triamterene?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If used, monitor serum potassium and creatinine closely and ensure adequate hydration.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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