Drug interactions
Celecoxib + Valsartan
Severity: Moderate
Celecoxib and Valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Celecoxib can blunt the antihypertensive effect of valsartan and may worsen renal function, particularly in elderly or volume-depleted patients. Both drugs can also raise serum potassium, increasing the risk of hyperkalemia.
What this interaction means in plain words
Celecoxib and Valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Celecoxib belongs to Musculoskeletal; Valsartan belongs to Cardiovascular.
Why it happens
NSAID inhibition of vasodilatory renal prostaglandins reduces renal perfusion and sodium excretion, which combined with angiotensin receptor blockade impairs glomerular filtration and potassium handling.
What to do
Ensure adequate hydration and monitor blood pressure, serum creatinine and potassium after starting or changing celecoxib. Avoid or minimize the combination in patients with volume depletion or renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Other interactions of Valsartan
- Aliskiren + Valsartan Contraindicated
- Sparsentan + Valsartan Contraindicated
- Aldesleukin + Valsartan Major
- Amifostine + Valsartan Major
- Amiloride + Valsartan Major
- Amlodipine-benazepril + Valsartan Major
Frequently asked questions
Can I take Celecoxib with Valsartan?
MediHelp rates the interaction as moderate. Celecoxib and Valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Celecoxib can blunt the antihypertensive effect of valsartan and may worsen renal function, particularly in elderly or volume-depleted patients. Both drugs can also raise serum potassium, increasing the risk of hyperkalemia.
How serious is the interaction between Celecoxib and Valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ensure adequate hydration and monitor blood pressure, serum creatinine and potassium after starting or changing celecoxib. Avoid or minimize the combination in patients with volume depletion or renal impairment.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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