Drug interactions
Celiprolol + Desflurane
Severity: Moderate
Celiprolol and Desflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Celiprolol is a beta-blocker with partial beta-2 agonism, and desflurane causes vasodilation and myocardial depression. Combined use can cause hypotension and bradycardia by limiting compensatory responses.
What this interaction means in plain words
Celiprolol and Desflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive cardiovascular depression from desflurane vasodilation and beta-1 blockade.
What to do
Monitor blood pressure and heart rate throughout anesthesia and adjust desflurane concentration. Keep vasopressors and atropine available.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desflurane
Frequently asked questions
Can I take Celiprolol with Desflurane?
MediHelp rates the interaction as moderate. Celiprolol and Desflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Celiprolol is a beta-blocker with partial beta-2 agonism, and desflurane causes vasodilation and myocardial depression. Combined use can cause hypotension and bradycardia by limiting compensatory responses.
How serious is the interaction between Celiprolol and Desflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate throughout anesthesia and adjust desflurane concentration. Keep vasopressors and atropine available.
What other medicines interact with Desflurane?
MediHelp also lists interactions of Desflurane with, for example, Amisulpride, Anagrelide, Arsenic trioxide. The full list is on the Desflurane page.
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