Drug interactions
Celiprolol + Labetalol
Severity: Moderate
Celiprolol and Labetalol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents are beta-blockers, so combining them duplicates therapy and increases hypotension and bradycardia without clear benefit.
What this interaction means in plain words
Celiprolol and Labetalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive beta-adrenergic blockade, with added alpha-1 blockade from labetalol and weak beta-2 agonism from celiprolol.
What to do
Use a single beta-blocker and titrate the dose. If both are given, monitor heart rate and blood pressure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Labetalol
- Amifostine + Labetalol Major
- Amiodarone + Labetalol Major
- Atenolol-chlorthalidone + Labetalol Major
- Atenolol + Labetalol Major
- Betaxolol + Labetalol Major
- Bisoprolol + Labetalol Major
Frequently asked questions
Can I take Celiprolol with Labetalol?
MediHelp rates the interaction as moderate. Celiprolol and Labetalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents are beta-blockers, so combining them duplicates therapy and increases hypotension and bradycardia without clear benefit.
How serious is the interaction between Celiprolol and Labetalol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a single beta-blocker and titrate the dose. If both are given, monitor heart rate and blood pressure.
What other medicines interact with Labetalol?
MediHelp also lists interactions of Labetalol with, for example, Amifostine, Amiodarone, Atenolol-chlorthalidone. The full list is on the Labetalol page.
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