Drug interactions
Celiprolol + Mefloquine
Severity: Moderate
Celiprolol and Mefloquine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mefloquine can slow heart rate and conduction, and celiprolol adds beta-blocking effects. Combined use may cause bradycardia or AV block.
What this interaction means in plain words
Celiprolol and Mefloquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive negative chronotropic and dromotropic effects.
What to do
Monitor pulse and ECG during co-administration. Consider an alternative antimalarial if bradyarrhythmia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mefloquine
- Arsenic trioxide + Mefloquine Contraindicated
- Dronedarone + Mefloquine Contraindicated
- Ibutilide + Mefloquine Contraindicated
- Levoketoconazole + Mefloquine Contraindicated
- Mefloquine + Nilotinib Contraindicated
- Mefloquine + Pimozide Contraindicated
Frequently asked questions
Can I take Celiprolol with Mefloquine?
MediHelp rates the interaction as moderate. Celiprolol and Mefloquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mefloquine can slow heart rate and conduction, and celiprolol adds beta-blocking effects. Combined use may cause bradycardia or AV block.
How serious is the interaction between Celiprolol and Mefloquine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor pulse and ECG during co-administration. Consider an alternative antimalarial if bradyarrhythmia occurs.
What other medicines interact with Mefloquine?
MediHelp also lists interactions of Mefloquine with, for example, Arsenic trioxide, Dronedarone, Ibutilide. The full list is on the Mefloquine page.
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