Drug interactions
Celiprolol + Metoprolol
Severity: Moderate
Celiprolol and Metoprolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Two beta-blockers given together duplicate therapy and increase the risk of bradycardia, hypotension and conduction block without clear added benefit.
What this interaction means in plain words
Celiprolol and Metoprolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive beta-adrenergic blockade (therapeutic duplication).
What to do
Use a single beta-blocker. Monitor heart rate and blood pressure if combined.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metoprolol
- Metoprolol + Thioridazine Contraindicated
- Amifostine + Metoprolol Major
- Amiodarone + Metoprolol Major
- Atenolol-chlorthalidone + Metoprolol Major
- Atenolol + Metoprolol Major
- Betaxolol + Metoprolol Major
Frequently asked questions
Can I take Celiprolol with Metoprolol?
MediHelp rates the interaction as moderate. Celiprolol and Metoprolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Two beta-blockers given together duplicate therapy and increase the risk of bradycardia, hypotension and conduction block without clear added benefit.
How serious is the interaction between Celiprolol and Metoprolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a single beta-blocker. Monitor heart rate and blood pressure if combined.
What other medicines interact with Metoprolol?
MediHelp also lists interactions of Metoprolol with, for example, Thioridazine, Amifostine, Amiodarone. The full list is on the Metoprolol page.
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