Drug interactions
Celiprolol + Piroxicam
Severity: Moderate
Celiprolol and Piroxicam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Prolonged NSAID use can blunt the blood pressure lowering effect of beta-blockers such as celiprolol. Blood pressure control may deteriorate, especially with regular rather than occasional NSAID use.
What this interaction means in plain words
Celiprolol and Piroxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAIDs inhibit renal and vascular prostaglandin synthesis, causing sodium and water retention and vasoconstriction that oppose the antihypertensive effect.
What to do
Monitor blood pressure when piroxicam is used regularly with celiprolol and adjust antihypertensive therapy if needed. Use the lowest effective NSAID dose for the shortest time.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Piroxicam
- Ketorolac intranasal + Piroxicam Contraindicated
- Ketorolac + Piroxicam Contraindicated
- Aceclofenac + Piroxicam Major
- Acemetacin + Piroxicam Major
- Acetylsalicylic acid + Piroxicam Major
- Alteplase + Piroxicam Major
Frequently asked questions
Can I take Celiprolol with Piroxicam?
MediHelp rates the interaction as moderate. Celiprolol and Piroxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Prolonged NSAID use can blunt the blood pressure lowering effect of beta-blockers such as celiprolol. Blood pressure control may deteriorate, especially with regular rather than occasional NSAID use.
How serious is the interaction between Celiprolol and Piroxicam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when piroxicam is used regularly with celiprolol and adjust antihypertensive therapy if needed. Use the lowest effective NSAID dose for the shortest time.
What other medicines interact with Piroxicam?
MediHelp also lists interactions of Piroxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Piroxicam page.
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