Drug interactions
Celiprolol + Tizanidine
Severity: Moderate
Celiprolol and Tizanidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can reduce blood pressure and heart rate. The combination may lead to additive hypotension, dizziness or bradycardia.
What this interaction means in plain words
Celiprolol and Tizanidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypotensive effects of central alpha-2 agonism and beta-blockade.
What to do
Monitor blood pressure and pulse at initiation and after dose changes. Lower the dose of one drug if symptomatic hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tizanidine
- Ciprofloxacin + Tizanidine Contraindicated
- Fluvoxamine + Tizanidine Contraindicated
- Pefloxacin + Tizanidine Contraindicated
- Pipemidic acid + Tizanidine Contraindicated
- Benzhydrocodone / acetaminophen + Tizanidine Major
- Brexanolone + Tizanidine Major
Frequently asked questions
Can I take Celiprolol with Tizanidine?
MediHelp rates the interaction as moderate. Celiprolol and Tizanidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can reduce blood pressure and heart rate. The combination may lead to additive hypotension, dizziness or bradycardia.
How serious is the interaction between Celiprolol and Tizanidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and pulse at initiation and after dose changes. Lower the dose of one drug if symptomatic hypotension develops.
What other medicines interact with Tizanidine?
MediHelp also lists interactions of Tizanidine with, for example, Ciprofloxacin, Fluvoxamine, Pefloxacin. The full list is on the Tizanidine page.
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