Drug interactions
Cenobamate + Clarithromycin
Severity: Moderate
Cenobamate and Clarithromycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cenobamate is a CYP3A4 inducer and may lower clarithromycin levels, possibly compromising antibacterial efficacy. Formation of the active 14-hydroxy metabolite may change.
What this interaction means in plain words
Cenobamate and Clarithromycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cenobamate belongs to Central Nervous System; Clarithromycin belongs to Anti Bacterial.
Why it happens
Cenobamate induces CYP3A4, increasing clarithromycin clearance.
What to do
Monitor clinical response to clarithromycin and consider an alternative antibiotic if treatment fails.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clarithromycin
- Astemizole + Clarithromycin Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Cisapride + Clarithromycin Contraindicated
- Clarithromycin + Colchicine Contraindicated
- Clarithromycin + Conivaptan Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
Other interactions of Cenobamate
Frequently asked questions
Can I take Cenobamate with Clarithromycin?
MediHelp rates the interaction as moderate. Cenobamate and Clarithromycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cenobamate is a CYP3A4 inducer and may lower clarithromycin levels, possibly compromising antibacterial efficacy. Formation of the active 14-hydroxy metabolite may change.
How serious is the interaction between Cenobamate and Clarithromycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response to clarithromycin and consider an alternative antibiotic if treatment fails.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
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