Drug interactions
Cenobamate + Clomipramine
Severity: Moderate
Cenobamate and Clomipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause somnolence and dizziness, so combined use may increase sedation and impair coordination. Clomipramine also lowers the seizure threshold, which may oppose the antiseizure effect of cenobamate.
What this interaction means in plain words
Cenobamate and Clomipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cenobamate belongs to Central Nervous System; Clomipramine belongs to Central Nervous System.
Why it happens
Additive CNS depression, plus a pharmacodynamic lowering of seizure threshold by clomipramine.
What to do
Monitor for sedation and seizure control. Adjust doses as needed and counsel patients on driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Other interactions of Cenobamate
Frequently asked questions
Can I take Cenobamate with Clomipramine?
MediHelp rates the interaction as moderate. Cenobamate and Clomipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause somnolence and dizziness, so combined use may increase sedation and impair coordination. Clomipramine also lowers the seizure threshold, which may oppose the antiseizure effect of cenobamate.
How serious is the interaction between Cenobamate and Clomipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and seizure control. Adjust doses as needed and counsel patients on driving.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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