Drug interactions
Cenobamate + Clorazepate
Severity: Moderate
Cenobamate and Clorazepate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cenobamate causes somnolence and dizziness, which may add to clorazepate sedation. Cenobamate also induces CYP3A4 and may lower exposure to some benzodiazepines, though clorazepate's active metabolite nordazepam is mainly cleared by other pathways as well.
What this interaction means in plain words
Cenobamate and Clorazepate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cenobamate belongs to Central Nervous System; Clorazepate belongs to Central Nervous System.
Why it happens
Additive CNS depression plus possible CYP3A4 induction by cenobamate reducing benzodiazepine levels.
What to do
Monitor sedation and seizure or anxiety control, and adjust the clorazepate dose as needed. Titrate cenobamate slowly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clorazepate
- Calcium / magnesium / potassium / sodium oxybates + Clorazepate Contraindicated
- Clorazepate + Sodium oxybate Contraindicated
- Alfentanil + Clorazepate Major
- Alprazolam + Clorazepate Major
- Amobarbital + Clorazepate Major
- Belladonna and opium + Clorazepate Major
Other interactions of Cenobamate
Frequently asked questions
Can I take Cenobamate with Clorazepate?
MediHelp rates the interaction as moderate. Cenobamate and Clorazepate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cenobamate causes somnolence and dizziness, which may add to clorazepate sedation. Cenobamate also induces CYP3A4 and may lower exposure to some benzodiazepines, though clorazepate's active metabolite nordazepam is mainly cleared by other pathways as well.
How serious is the interaction between Cenobamate and Clorazepate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and seizure or anxiety control, and adjust the clorazepate dose as needed. Titrate cenobamate slowly.
What other medicines interact with Clorazepate?
MediHelp also lists interactions of Clorazepate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clorazepate page.
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