Drug interactions
Cenobamate + Crizotinib
Severity: Moderate
Cenobamate and Crizotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cenobamate is a CYP3A4 inducer and may reduce crizotinib exposure, risking reduced anticancer effect.
What this interaction means in plain words
Cenobamate and Crizotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cenobamate belongs to Central Nervous System; Crizotinib belongs to Oncology.
Why it happens
Cenobamate induces CYP3A4, increasing crizotinib clearance.
What to do
Monitor for reduced tumor response and consider an alternative antiseizure drug without induction if feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Other interactions of Cenobamate
Frequently asked questions
Can I take Cenobamate with Crizotinib?
MediHelp rates the interaction as moderate. Cenobamate and Crizotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cenobamate is a CYP3A4 inducer and may reduce crizotinib exposure, risking reduced anticancer effect.
How serious is the interaction between Cenobamate and Crizotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced tumor response and consider an alternative antiseizure drug without induction if feasible.
What other medicines interact with Crizotinib?
MediHelp also lists interactions of Crizotinib with, for example, Flibanserin, Lomitapide, Lonafarnib. The full list is on the Crizotinib page.
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