Drug interactions
Cenobamate + Dapsone
Severity: Minor
Cenobamate and Dapsone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cenobamate can induce CYP3A4, which may lower dapsone exposure. Reduced dapsone concentrations could weaken its antimicrobial or anti-inflammatory effect, although the clinical impact has not been well characterised.
What this interaction means in plain words
Cenobamate and Dapsone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cenobamate belongs to Central Nervous System; Dapsone belongs to Anti Bacterial.
Why it happens
Cenobamate induces CYP3A4, increasing the oxidative metabolism of dapsone.
What to do
Monitor clinical response to dapsone when cenobamate is started or titrated. Consider a dapsone dose increase only if there is loss of therapeutic effect.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dapsone
- Bcg vaccine live + Dapsone Major
- Dapsone + Primaquine Major
- Apalutamide + Dapsone Moderate
- Belzutifan + Dapsone Moderate
- Bosentan + Dapsone Moderate
- Bupivacaine implant + Dapsone Moderate
Other interactions of Cenobamate
Frequently asked questions
Can I take Cenobamate with Dapsone?
MediHelp rates the interaction as minor. Cenobamate and Dapsone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cenobamate can induce CYP3A4, which may lower dapsone exposure. Reduced dapsone concentrations could weaken its antimicrobial or anti-inflammatory effect, although the clinical impact has not been well characterised.
How serious is the interaction between Cenobamate and Dapsone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response to dapsone when cenobamate is started or titrated. Consider a dapsone dose increase only if there is loss of therapeutic effect.
What other medicines interact with Dapsone?
MediHelp also lists interactions of Dapsone with, for example, Bcg vaccine live, Primaquine, Apalutamide. The full list is on the Dapsone page.
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