Drug interactions
Cenobamate + Dasatinib
Severity: Moderate
Cenobamate and Dasatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cenobamate induces CYP3A4 and can lower dasatinib concentrations. Loss of efficacy of dasatinib is a concern.
What this interaction means in plain words
Cenobamate and Dasatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cenobamate belongs to Central Nervous System; Dasatinib belongs to Oncology.
Why it happens
Cenobamate induction of CYP3A4 accelerates dasatinib clearance.
What to do
Monitor disease response closely and consider an increased dasatinib dose per labeling, or choose a non-inducing anticonvulsant.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Other interactions of Cenobamate
Frequently asked questions
Can I take Cenobamate with Dasatinib?
MediHelp rates the interaction as moderate. Cenobamate and Dasatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cenobamate induces CYP3A4 and can lower dasatinib concentrations. Loss of efficacy of dasatinib is a concern.
How serious is the interaction between Cenobamate and Dasatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor disease response closely and consider an increased dasatinib dose per labeling, or choose a non-inducing anticonvulsant.
What other medicines interact with Dasatinib?
MediHelp also lists interactions of Dasatinib with, for example, Saquinavir, Thioridazine, Adagrasib. The full list is on the Dasatinib page.
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