Drug interactions
Cenobamate + Dronabinol
Severity: Moderate
Cenobamate and Dronabinol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cenobamate induces CYP3A4 and may reduce dronabinol concentrations, lowering its effectiveness. Both drugs also cause somnolence and dizziness, so combined CNS depression is likely.
What this interaction means in plain words
Cenobamate and Dronabinol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cenobamate belongs to Central Nervous System; Dronabinol belongs to Central Nervous System.
Why it happens
Cenobamate induction of CYP3A4 increases dronabinol clearance, with additive CNS depressant effects.
What to do
Monitor therapeutic response and increase the dronabinol dose if needed. Monitor for excess sedation and caution about driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dronabinol
- Cefotetan + Dronabinol Contraindicated
- Disulfiram + Dronabinol Contraindicated
- Dronabinol + Midazolam intranasal Major
- Dronabinol + Zuranolone Major
- Amobarbital + Dronabinol Moderate
- Apalutamide + Dronabinol Moderate
Other interactions of Cenobamate
Frequently asked questions
Can I take Cenobamate with Dronabinol?
MediHelp rates the interaction as moderate. Cenobamate and Dronabinol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cenobamate induces CYP3A4 and may reduce dronabinol concentrations, lowering its effectiveness. Both drugs also cause somnolence and dizziness, so combined CNS depression is likely.
How serious is the interaction between Cenobamate and Dronabinol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor therapeutic response and increase the dronabinol dose if needed. Monitor for excess sedation and caution about driving.
What other medicines interact with Dronabinol?
MediHelp also lists interactions of Dronabinol with, for example, Cefotetan, Disulfiram, Midazolam intranasal. The full list is on the Dronabinol page.
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