Drug interactions
Cenobamate + Eplerenone
Severity: Moderate
Cenobamate and Eplerenone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cenobamate induces CYP3A4, which is the main route of eplerenone clearance. Eplerenone concentrations may decrease and its therapeutic effect may be reduced.
What this interaction means in plain words
Cenobamate and Eplerenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cenobamate belongs to Central Nervous System; Eplerenone belongs to Cardiovascular.
Why it happens
CYP3A4 induction by cenobamate, increasing eplerenone metabolism.
What to do
Monitor blood pressure and clinical response, and titrate eplerenone upward if needed. Reassess the dose when cenobamate is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eplerenone
- Amiloride + Eplerenone Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Clarithromycin + Eplerenone Contraindicated
- Cobicistat + Eplerenone Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Eplerenone Contraindicated
- Ensitrelvir + Eplerenone Contraindicated
Other interactions of Cenobamate
Frequently asked questions
Can I take Cenobamate with Eplerenone?
MediHelp rates the interaction as moderate. Cenobamate and Eplerenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cenobamate induces CYP3A4, which is the main route of eplerenone clearance. Eplerenone concentrations may decrease and its therapeutic effect may be reduced.
How serious is the interaction between Cenobamate and Eplerenone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and clinical response, and titrate eplerenone upward if needed. Reassess the dose when cenobamate is stopped.
What other medicines interact with Eplerenone?
MediHelp also lists interactions of Eplerenone with, for example, Amiloride, Atazanavir, Clarithromycin. The full list is on the Eplerenone page.
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