Drug interactions
Cenobamate + Eslicarbazepine
Severity: Moderate
Cenobamate and Eslicarbazepine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are antiseizure medicines that depress the CNS, so together they can cause additive dizziness, somnolence, and impaired coordination. Cenobamate also inhibits CYP2C19 and induces CYP3A4, which may change levels of co-administered antiseizure drugs.
What this interaction means in plain words
Cenobamate and Eslicarbazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cenobamate belongs to Central Nervous System; Eslicarbazepine belongs to Central Nervous System.
Why it happens
Additive CNS depression, together with cenobamate-mediated effects on CYP enzymes.
What to do
Monitor for sedation, dizziness, and ataxia, and titrate cautiously. Reduce the dose of one agent if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eslicarbazepine
- Eslicarbazepine + Mavacamten Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Eslicarbazepine Major
- Avapritinib + Eslicarbazepine Major
- Bedaquiline + Eslicarbazepine Major
- Benzhydrocodone / acetaminophen + Eslicarbazepine Major
Other interactions of Cenobamate
Frequently asked questions
Can I take Cenobamate with Eslicarbazepine?
MediHelp rates the interaction as moderate. Cenobamate and Eslicarbazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs are antiseizure medicines that depress the CNS, so together they can cause additive dizziness, somnolence, and impaired coordination. Cenobamate also inhibits CYP2C19 and induces CYP3A4, which may change levels of co-administered antiseizure drugs.
How serious is the interaction between Cenobamate and Eslicarbazepine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, dizziness, and ataxia, and titrate cautiously. Reduce the dose of one agent if adverse effects occur.
What other medicines interact with Eslicarbazepine?
MediHelp also lists interactions of Eslicarbazepine with, for example, Mavacamten, Rilpivirine, Artemether / lumefantrine. The full list is on the Eslicarbazepine page.
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