Drug interactions
Cenobamate + Haloperidol
Severity: Moderate
Cenobamate and Haloperidol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cenobamate induces CYP3A4 and may lower haloperidol levels, reducing antipsychotic control. Cenobamate also causes sedation and can shorten the QT interval, so combined effects should be watched.
What this interaction means in plain words
Cenobamate and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cenobamate belongs to Central Nervous System; Haloperidol belongs to Central Nervous System.
Why it happens
Cenobamate induction of CYP3A4 increases haloperidol clearance.
What to do
Monitor clinical response and consider raising the haloperidol dose; reduce it again if cenobamate is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Other interactions of Cenobamate
Frequently asked questions
Can I take Cenobamate with Haloperidol?
MediHelp rates the interaction as moderate. Cenobamate and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cenobamate induces CYP3A4 and may lower haloperidol levels, reducing antipsychotic control. Cenobamate also causes sedation and can shorten the QT interval, so combined effects should be watched.
How serious is the interaction between Cenobamate and Haloperidol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and consider raising the haloperidol dose; reduce it again if cenobamate is stopped.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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