Drug interactions
Cenobamate + Itraconazole
Severity: Moderate
Cenobamate and Itraconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cenobamate induces CYP3A4 and may lower itraconazole concentrations, risking antifungal treatment failure.
What this interaction means in plain words
Cenobamate and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cenobamate belongs to Central Nervous System; Itraconazole belongs to Anti Fungals.
Why it happens
Cenobamate induces CYP3A4, increasing itraconazole metabolism.
What to do
Monitor itraconazole serum levels and clinical response, and increase the dose or choose an alternative antifungal if levels are subtherapeutic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Cenobamate
Frequently asked questions
Can I take Cenobamate with Itraconazole?
MediHelp rates the interaction as moderate. Cenobamate and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cenobamate induces CYP3A4 and may lower itraconazole concentrations, risking antifungal treatment failure.
How serious is the interaction between Cenobamate and Itraconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor itraconazole serum levels and clinical response, and increase the dose or choose an alternative antifungal if levels are subtherapeutic.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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