Drug interactions
Cenobamate + Lovastatin
Severity: Moderate
Cenobamate and Lovastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cenobamate can lower lovastatin concentrations and may reduce its cholesterol-lowering effect.
What this interaction means in plain words
Cenobamate and Lovastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cenobamate belongs to Central Nervous System; Lovastatin belongs to Cardiovascular.
Why it happens
Cenobamate induces CYP3A4, increasing the metabolism of lovastatin.
What to do
Monitor the lipid profile and increase the lovastatin dose if needed, or switch to a statin not dependent on CYP3A4.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lovastatin
- Atazanavir + Lovastatin Contraindicated
- Clarithromycin + Lovastatin Contraindicated
- Cobicistat + Lovastatin Contraindicated
- Conivaptan + Lovastatin Contraindicated
- Darunavir + Lovastatin Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Lovastatin Contraindicated
Other interactions of Cenobamate
Frequently asked questions
Can I take Cenobamate with Lovastatin?
MediHelp rates the interaction as moderate. Cenobamate and Lovastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cenobamate can lower lovastatin concentrations and may reduce its cholesterol-lowering effect.
How serious is the interaction between Cenobamate and Lovastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor the lipid profile and increase the lovastatin dose if needed, or switch to a statin not dependent on CYP3A4.
What other medicines interact with Lovastatin?
MediHelp also lists interactions of Lovastatin with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Lovastatin page.
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