Drug interactions
Cenobamate + Mefloquine
Severity: Moderate
Cenobamate and Mefloquine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cenobamate can induce CYP3A4 and may lower mefloquine concentrations. This could reduce antimalarial efficacy, whether used for prophylaxis or treatment.
What this interaction means in plain words
Cenobamate and Mefloquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cenobamate belongs to Central Nervous System; Mefloquine belongs to Anti Parasitic.
Why it happens
Cenobamate induces CYP3A4, increasing the metabolism of mefloquine.
What to do
Monitor for reduced antimalarial effect and consider an alternative antimalarial that is not CYP3A4-dependent. If used, dose adjustment may be needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mefloquine
- Arsenic trioxide + Mefloquine Contraindicated
- Dronedarone + Mefloquine Contraindicated
- Ibutilide + Mefloquine Contraindicated
- Levoketoconazole + Mefloquine Contraindicated
- Mefloquine + Nilotinib Contraindicated
- Mefloquine + Pimozide Contraindicated
Other interactions of Cenobamate
Frequently asked questions
Can I take Cenobamate with Mefloquine?
MediHelp rates the interaction as moderate. Cenobamate and Mefloquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cenobamate can induce CYP3A4 and may lower mefloquine concentrations. This could reduce antimalarial efficacy, whether used for prophylaxis or treatment.
How serious is the interaction between Cenobamate and Mefloquine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced antimalarial effect and consider an alternative antimalarial that is not CYP3A4-dependent. If used, dose adjustment may be needed.
What other medicines interact with Mefloquine?
MediHelp also lists interactions of Mefloquine with, for example, Arsenic trioxide, Dronedarone, Ibutilide. The full list is on the Mefloquine page.
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