Drug interactions
Cenobamate + Omeprazole
Severity: Moderate
Cenobamate and Omeprazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cenobamate inhibits CYP2C19 and induces CYP3A4, so omeprazole exposure can change in either direction depending on the pathway. The net effect is not predictable for every patient.
What this interaction means in plain words
Cenobamate and Omeprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cenobamate belongs to Central Nervous System; Omeprazole belongs to Gastrointestinal Tract.
Why it happens
Cenobamate inhibits CYP2C19 and induces CYP3A4, both of which metabolize omeprazole.
What to do
Monitor acid suppression response and adjust the omeprazole dose accordingly. Reduce the dose if adverse effects appear, or increase it if control is inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Omeprazole
- Mavacamten + Omeprazole Contraindicated
- Omeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Omeprazole Major
- Atazanavir + Omeprazole Major
- Citalopram + Omeprazole Major
- Clopidogrel + Omeprazole Major
Other interactions of Cenobamate
Frequently asked questions
Can I take Cenobamate with Omeprazole?
MediHelp rates the interaction as moderate. Cenobamate and Omeprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cenobamate inhibits CYP2C19 and induces CYP3A4, so omeprazole exposure can change in either direction depending on the pathway. The net effect is not predictable for every patient.
How serious is the interaction between Cenobamate and Omeprazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor acid suppression response and adjust the omeprazole dose accordingly. Reduce the dose if adverse effects appear, or increase it if control is inadequate.
What other medicines interact with Omeprazole?
MediHelp also lists interactions of Omeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Omeprazole page.
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