Drug interactions
Omeprazole + Rilpivirine
Severity: Contraindicated
Omeprazole and Rilpivirine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Omeprazole substantially lowers oral rilpivirine concentrations, which may cause virologic failure and NNRTI resistance. Labeling contraindicates the combination.
What this interaction means in plain words
Omeprazole and Rilpivirine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Omeprazole belongs to Gastrointestinal Tract; Rilpivirine belongs to Anti Virals.
Why it happens
Elevated gastric pH reduces absorption of oral rilpivirine, which needs an acidic environment.
What to do
Do not coadminister; choose a different acid-reducing strategy or antiretroviral. If acid suppression is essential, H2 blockers need timed separation (rilpivirine at least 4 hours before or 12 hours after).
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Omeprazole
- Mavacamten + Omeprazole Contraindicated
- Acalabrutinib + Omeprazole Major
- Atazanavir + Omeprazole Major
- Citalopram + Omeprazole Major
- Clopidogrel + Omeprazole Major
- Dacomitinib + Omeprazole Major
Other interactions of Rilpivirine
- Carbamazepine + Rilpivirine Contraindicated
- Dexamethasone + Rilpivirine Contraindicated
- Dexlansoprazole + Rilpivirine Contraindicated
- Efavirenz + Rilpivirine Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Esomeprazole + Rilpivirine Contraindicated
Frequently asked questions
Can I take Omeprazole with Rilpivirine?
MediHelp rates the interaction as contraindicated. Omeprazole and Rilpivirine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Omeprazole substantially lowers oral rilpivirine concentrations, which may cause virologic failure and NNRTI resistance. Labeling contraindicates the combination.
How serious is the interaction between Omeprazole and Rilpivirine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister; choose a different acid-reducing strategy or antiretroviral. If acid suppression is essential, H2 blockers need timed separation (rilpivirine at least 4 hours before or 12 hours after).
What other medicines interact with Omeprazole?
MediHelp also lists interactions of Omeprazole with, for example, Mavacamten, Acalabrutinib, Atazanavir. The full list is on the Omeprazole page.
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