Drug interactions
Atazanavir + Omeprazole
Severity: Major
Atazanavir and Omeprazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atazanavir needs an acidic environment to dissolve, and omeprazole substantially lowers its plasma concentrations. This can cause loss of virologic control and resistance.
What this interaction means in plain words
Atazanavir and Omeprazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Atazanavir belongs to Anti Virals; Omeprazole belongs to Gastrointestinal Tract.
Why it happens
Increased gastric pH reduces atazanavir solubility and absorption.
What to do
Avoid PPIs in treatment-experienced patients. In naive patients, use no more than omeprazole 20 mg daily, taken about 12 hours before ritonavir-boosted atazanavir.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Omeprazole
- Mavacamten + Omeprazole Contraindicated
- Omeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Omeprazole Major
- Citalopram + Omeprazole Major
- Clopidogrel + Omeprazole Major
- Dacomitinib + Omeprazole Major
Other interactions of Atazanavir
- Alfuzosin + Atazanavir Contraindicated
- Atazanavir + Avanafil Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Atazanavir + Ergotamine Contraindicated
Frequently asked questions
Can I take Atazanavir with Omeprazole?
MediHelp rates the interaction as major. Atazanavir and Omeprazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Atazanavir needs an acidic environment to dissolve, and omeprazole substantially lowers its plasma concentrations. This can cause loss of virologic control and resistance.
How serious is the interaction between Atazanavir and Omeprazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid PPIs in treatment-experienced patients. In naive patients, use no more than omeprazole 20 mg daily, taken about 12 hours before ritonavir-boosted atazanavir.
What other medicines interact with Omeprazole?
MediHelp also lists interactions of Omeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Omeprazole page.
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