Drug interactions
Cenobamate + Perphenazine
Severity: Moderate
Cenobamate and Perphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cenobamate commonly causes somnolence, dizziness and fatigue, and perphenazine adds sedative effects. Together they may increase drowsiness and impair coordination and alertness.
What this interaction means in plain words
Cenobamate and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cenobamate belongs to Central Nervous System; Perphenazine belongs to Central Nervous System.
Why it happens
Additive CNS depressant pharmacodynamic effects.
What to do
Monitor for excessive sedation and dizziness and titrate cenobamate slowly. Advise patients to avoid driving until tolerance is established.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Other interactions of Cenobamate
Frequently asked questions
Can I take Cenobamate with Perphenazine?
MediHelp rates the interaction as moderate. Cenobamate and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cenobamate commonly causes somnolence, dizziness and fatigue, and perphenazine adds sedative effects. Together they may increase drowsiness and impair coordination and alertness.
How serious is the interaction between Cenobamate and Perphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and dizziness and titrate cenobamate slowly. Advise patients to avoid driving until tolerance is established.
What other medicines interact with Perphenazine?
MediHelp also lists interactions of Perphenazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Perphenazine page.
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