Drug interactions
Cenobamate + Saxagliptin
Severity: Moderate
Cenobamate and Saxagliptin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cenobamate induces CYP3A4 and may lower saxagliptin and active metabolite exposure. Glycemic control could be reduced.
What this interaction means in plain words
Cenobamate and Saxagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cenobamate belongs to Central Nervous System; Saxagliptin belongs to Endocrine.
Why it happens
Induction of CYP3A4 increasing saxagliptin metabolism.
What to do
Monitor glycemic control and HbA1c; consider an alternative antidiabetic agent if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Saxagliptin
- Albiglutide + Saxagliptin Moderate
- Amlodipine-benazepril + Saxagliptin Moderate
- Aripiprazole + Saxagliptin Moderate
- Asenapine + Saxagliptin Moderate
- Atazanavir + Saxagliptin Moderate
- Benazepril + Saxagliptin Moderate
Other interactions of Cenobamate
Frequently asked questions
Can I take Cenobamate with Saxagliptin?
MediHelp rates the interaction as moderate. Cenobamate and Saxagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cenobamate induces CYP3A4 and may lower saxagliptin and active metabolite exposure. Glycemic control could be reduced.
How serious is the interaction between Cenobamate and Saxagliptin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glycemic control and HbA1c; consider an alternative antidiabetic agent if control worsens.
What other medicines interact with Saxagliptin?
MediHelp also lists interactions of Saxagliptin with, for example, Albiglutide, Amlodipine-benazepril, Aripiprazole. The full list is on the Saxagliptin page.
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