Drug interactions
Cenobamate + Sofosbuvir-velpatasvir-voxilaprevir
Severity: Moderate
Cenobamate and Sofosbuvir-velpatasvir-voxilaprevir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cenobamate is a weak-to-moderate inducer of CYP3A4 and CYP2B6, and may lower velpatasvir and voxilaprevir concentrations. Reduced exposure could compromise the hepatitis C cure rate.
What this interaction means in plain words
Cenobamate and Sofosbuvir-velpatasvir-voxilaprevir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cenobamate belongs to Central Nervous System; Sofosbuvir-velpatasvir-voxilaprevir belongs to Anti Virals.
Why it happens
Cenobamate induces CYP3A4, CYP2B6 and possibly P-gp, which increases the metabolism and efflux of velpatasvir and voxilaprevir.
What to do
Avoid the combination where an alternative antiseizure drug is feasible. If it cannot be avoided, confirm sustained virologic response carefully and check HCV RNA during follow-up.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sofosbuvir-velpatasvir-voxilaprevir
- Fosphenytoin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Phenobarbital + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Phenytoin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Primidone + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Rifampin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
Other interactions of Cenobamate
Frequently asked questions
Can I take Cenobamate with Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp rates the interaction as moderate. Cenobamate and Sofosbuvir-velpatasvir-voxilaprevir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cenobamate is a weak-to-moderate inducer of CYP3A4 and CYP2B6, and may lower velpatasvir and voxilaprevir concentrations. Reduced exposure could compromise the hepatitis C cure rate.
How serious is the interaction between Cenobamate and Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where an alternative antiseizure drug is feasible. If it cannot be avoided, confirm sustained virologic response carefully and check HCV RNA during follow-up.
What other medicines interact with Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp also lists interactions of Sofosbuvir-velpatasvir-voxilaprevir with, for example, Fosphenytoin, Phenobarbital, Phenytoin. The full list is on the Sofosbuvir-velpatasvir-voxilaprevir page.
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