Drug interactions
Cenobamate + Solifenacin
Severity: Moderate
Cenobamate and Solifenacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cenobamate is a CYP3A4 inducer and may speed up the clearance of solifenacin, which is mainly metabolised by CYP3A4. Lower solifenacin exposure could reduce control of overactive bladder symptoms.
What this interaction means in plain words
Cenobamate and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cenobamate belongs to Central Nervous System; Solifenacin belongs to Genitourinary.
Why it happens
Induction of CYP3A4 by cenobamate increases the metabolism of solifenacin.
What to do
Monitor for loss of antimuscarinic effect after cenobamate is started or the dose is raised. Increase the solifenacin dose within labeled limits if symptoms return.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Solifenacin
Other interactions of Cenobamate
Frequently asked questions
Can I take Cenobamate with Solifenacin?
MediHelp rates the interaction as moderate. Cenobamate and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cenobamate is a CYP3A4 inducer and may speed up the clearance of solifenacin, which is mainly metabolised by CYP3A4. Lower solifenacin exposure could reduce control of overactive bladder symptoms.
How serious is the interaction between Cenobamate and Solifenacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of antimuscarinic effect after cenobamate is started or the dose is raised. Increase the solifenacin dose within labeled limits if symptoms return.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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