Drug interactions
Cenobamate + Voriconazole
Severity: Moderate
Cenobamate and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cenobamate affects CYP2C19, and it may induce CYP3A4 as well as inhibit CYP2C19. The net effect on voriconazole is uncertain, but altered levels could lead to reduced efficacy or toxicity.
What this interaction means in plain words
Cenobamate and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cenobamate belongs to Central Nervous System; Voriconazole belongs to Anti Fungals.
Why it happens
Cenobamate modulates CYP2C19 and CYP3A4 activity, with an unpredictable net effect on voriconazole metabolism.
What to do
Monitor voriconazole trough concentrations and clinical response when starting or stopping cenobamate, and adjust the dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Cenobamate
Frequently asked questions
Can I take Cenobamate with Voriconazole?
MediHelp rates the interaction as moderate. Cenobamate and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cenobamate affects CYP2C19, and it may induce CYP3A4 as well as inhibit CYP2C19. The net effect on voriconazole is uncertain, but altered levels could lead to reduced efficacy or toxicity.
How serious is the interaction between Cenobamate and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor voriconazole trough concentrations and clinical response when starting or stopping cenobamate, and adjust the dose accordingly.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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