Drug interactions
Ethacrynic acid + Furosemide
Severity: Major
Ethacrynic acid and Furosemide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are loop diuretics, so combining them gives no therapeutic advantage and adds to the risk of ototoxicity, profound diuresis, and electrolyte depletion. Hearing damage can be permanent and the risk rises with high doses, renal impairment, or rapid infusion.
What this interaction means in plain words
Ethacrynic acid and Furosemide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ethacrynic acid belongs to Cardiovascular; Furosemide belongs to Cardiovascular.
Why it happens
Duplicate loop diuretic action with additive inhibition of the Na-K-2Cl cotransporter, including in the cochlea, producing additive ototoxicity and volume and electrolyte depletion.
What to do
Avoid concurrent use of two loop diuretics; use a single agent and, if resistance occurs, add a thiazide-type diuretic instead. Monitor hearing, renal function, and electrolytes if exposure cannot be avoided.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Furosemide
- Amifostine + Furosemide Major
- Amikacin + Furosemide Major
- Carbenoxolone + Furosemide Major
- Cephaloridine + Furosemide Major
- Cisplatin + Furosemide Major
- Digoxin + Furosemide Major
Other interactions of Ethacrynic acid
Frequently asked questions
Can I take Ethacrynic acid with Furosemide?
MediHelp rates the interaction as major. Ethacrynic acid and Furosemide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both are loop diuretics, so combining them gives no therapeutic advantage and adds to the risk of ototoxicity, profound diuresis, and electrolyte depletion. Hearing damage can be permanent and the risk rises with high doses, renal impairment, or rapid infusion.
How serious is the interaction between Ethacrynic acid and Furosemide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of two loop diuretics; use a single agent and, if resistance occurs, add a thiazide-type diuretic instead. Monitor hearing, renal function, and electrolytes if exposure cannot be avoided.
What other medicines interact with Furosemide?
MediHelp also lists interactions of Furosemide with, for example, Amifostine, Amikacin, Carbenoxolone. The full list is on the Furosemide page.
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