Drug interactions
Ceritinib + Pimozide
Severity: Contraindicated
Ceritinib and Pimozide: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ceritinib prolongs the QT interval and is also a CYP3A4 inhibitor, which can raise pimozide concentrations. The combination substantially increases the risk of torsades de pointes.
What this interaction means in plain words
Ceritinib and Pimozide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Ceritinib belongs to Oncology; Pimozide belongs to Central Nervous System.
Why it happens
Additive QT prolongation plus CYP3A4 inhibition reducing pimozide metabolism.
What to do
Avoid the combination and choose an alternative to pimozide during ceritinib therapy. If unavoidable, monitor ECG and electrolytes closely.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Other interactions of Ceritinib
- Ceritinib + Cisapride Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Ceritinib + Thioridazine Contraindicated
- Ceritinib + Tolvaptan Contraindicated
- Ado-trastuzumab + Ceritinib Major
Frequently asked questions
Can I take Ceritinib with Pimozide?
MediHelp rates the interaction as contraindicated. Ceritinib and Pimozide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ceritinib prolongs the QT interval and is also a CYP3A4 inhibitor, which can raise pimozide concentrations. The combination substantially increases the risk of torsades de pointes.
How serious is the interaction between Ceritinib and Pimozide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose an alternative to pimozide during ceritinib therapy. If unavoidable, monitor ECG and electrolytes closely.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
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