Drug interactions
Ceritinib + Cisapride
Severity: Contraindicated
Ceritinib and Cisapride: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ceritinib can prolong the QT interval and cause bradycardia, and it inhibits CYP3A4, the main route of cisapride clearance. Cisapride exposure and QT risk can therefore both rise, risking torsades de pointes.
What this interaction means in plain words
Ceritinib and Cisapride are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Ceritinib belongs to Oncology; Cisapride belongs to Gastrointestinal Tract.
Why it happens
Additive QT prolongation plus CYP3A4 inhibition by ceritinib that raises cisapride concentrations.
What to do
Do not coadminister; stop cisapride and use an alternative prokinetic during ceritinib therapy.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Cisapride
- Apomorphine + Cisapride Contraindicated
- Artemether + Cisapride Contraindicated
- Azithromycin + Cisapride Contraindicated
- Chloroquine + Cisapride Contraindicated
- Cisapride + Citalopram Contraindicated
- Cisapride + Clarithromycin Contraindicated
Other interactions of Ceritinib
- Ceritinib + Eletriptan Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Ceritinib + Pimozide Contraindicated
- Ceritinib + Thioridazine Contraindicated
- Ceritinib + Tolvaptan Contraindicated
- Ado-trastuzumab + Ceritinib Major
Frequently asked questions
Can I take Ceritinib with Cisapride?
MediHelp rates the interaction as contraindicated. Ceritinib and Cisapride are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ceritinib can prolong the QT interval and cause bradycardia, and it inhibits CYP3A4, the main route of cisapride clearance. Cisapride exposure and QT risk can therefore both rise, risking torsades de pointes.
How serious is the interaction between Ceritinib and Cisapride?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister; stop cisapride and use an alternative prokinetic during ceritinib therapy.
What other medicines interact with Cisapride?
MediHelp also lists interactions of Cisapride with, for example, Apomorphine, Artemether, Azithromycin. The full list is on the Cisapride page.
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