Drug interactions
Certolizumab pegol + Fingolimod
Severity: Moderate
Certolizumab pegol and Fingolimod: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fingolimod traps lymphocytes in lymph nodes, lowering circulating counts, and certolizumab blocks TNF-alpha. Used together they may increase the risk of serious infection, and fingolimod's effect persists for weeks after stopping.
What this interaction means in plain words
Certolizumab pegol and Fingolimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Certolizumab pegol belongs to Musculoskeletal; Fingolimod belongs to Central Nervous System.
Why it happens
Additive immunosuppression from S1P receptor modulation and TNF-alpha inhibition.
What to do
Monitor for infection and lymphocyte counts, and avoid the combination unless benefit is clear. Allow for fingolimod's prolonged effect when switching therapies.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Certolizumab pegol and Fingolimod, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Certolizumab pegol
- Adenovirus types 4 and 7 live + Certolizumab pegol Contraindicated
- Bcg intravesical live + Certolizumab pegol Contraindicated
- Bcg vaccine live + Certolizumab pegol Contraindicated
- Certolizumab pegol + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Certolizumab pegol + Measles mumps and rubella vaccine Contraindicated
- Certolizumab pegol + Measles mumps and rubella vaccine live Contraindicated
Other interactions of Fingolimod
- Adenovirus types 4 and 7 live + Fingolimod Contraindicated
- Bcg vaccine live + Fingolimod Contraindicated
- Fingolimod + Pimozide Contraindicated
- Fingolimod + Ponesimod Contraindicated
- Fingolimod + Quinidine Contraindicated
- Fingolimod + Siponimod Contraindicated
Frequently asked questions
Can I take Certolizumab pegol with Fingolimod?
MediHelp rates the interaction as moderate. Certolizumab pegol and Fingolimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fingolimod traps lymphocytes in lymph nodes, lowering circulating counts, and certolizumab blocks TNF-alpha. Used together they may increase the risk of serious infection, and fingolimod's effect persists for weeks after stopping.
How serious is the interaction between Certolizumab pegol and Fingolimod?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for infection and lymphocyte counts, and avoid the combination unless benefit is clear. Allow for fingolimod's prolonged effect when switching therapies.
What other medicines interact with Certolizumab pegol?
MediHelp also lists interactions of Certolizumab pegol with, for example, Adenovirus types 4 and 7 live, Bcg intravesical live, Bcg vaccine live. The full list is on the Certolizumab pegol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
