Drug interactions
Certolizumab pegol + Siponimod
Severity: Moderate
Certolizumab pegol and Siponimod: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Siponimod lowers peripheral lymphocyte counts and certolizumab blocks TNF-alpha. Combined use may increase risk of serious infection.
What this interaction means in plain words
Certolizumab pegol and Siponimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Certolizumab pegol belongs to Musculoskeletal; Siponimod belongs to Central Nervous System.
Why it happens
Additive immunosuppression from S1P receptor modulation and TNF-alpha inhibition.
What to do
Monitor for infection and lymphocyte counts during combined treatment. Take into account the lasting immune effects of each drug when switching therapies.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Certolizumab pegol
- Adenovirus types 4 and 7 live + Certolizumab pegol Contraindicated
- Bcg intravesical live + Certolizumab pegol Contraindicated
- Bcg vaccine live + Certolizumab pegol Contraindicated
- Certolizumab pegol + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Certolizumab pegol + Measles mumps and rubella vaccine Contraindicated
- Certolizumab pegol + Measles mumps and rubella vaccine live Contraindicated
Other interactions of Siponimod
- Cladribine + Siponimod Contraindicated
- Fingolimod + Siponimod Contraindicated
- Fluconazole + Siponimod Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Siponimod Contraindicated
- Ponesimod + Siponimod Contraindicated
- Siponimod + Thioridazine Contraindicated
Frequently asked questions
Can I take Certolizumab pegol with Siponimod?
MediHelp rates the interaction as moderate. Certolizumab pegol and Siponimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Siponimod lowers peripheral lymphocyte counts and certolizumab blocks TNF-alpha. Combined use may increase risk of serious infection.
How serious is the interaction between Certolizumab pegol and Siponimod?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for infection and lymphocyte counts during combined treatment. Take into account the lasting immune effects of each drug when switching therapies.
What other medicines interact with Certolizumab pegol?
MediHelp also lists interactions of Certolizumab pegol with, for example, Adenovirus types 4 and 7 live, Bcg intravesical live, Bcg vaccine live. The full list is on the Certolizumab pegol page.
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