Drug interactions
Certolizumab pegol + Ublituximab
Severity: Moderate
Certolizumab pegol and Ublituximab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs suppress immunity by different mechanisms, so combined use may increase the risk of serious infection. B-cell depletion from ublituximab lasts for months.
What this interaction means in plain words
Certolizumab pegol and Ublituximab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Certolizumab pegol belongs to Musculoskeletal; Ublituximab belongs to Miscellaneous.
Why it happens
Additive immunosuppression from TNF-alpha blockade and anti-CD20 B-cell depletion.
What to do
Monitor closely for infection and screen for hepatitis B and tuberculosis before therapy. Avoid the combination unless clearly justified.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Certolizumab pegol
- Adenovirus types 4 and 7 live + Certolizumab pegol Contraindicated
- Bcg intravesical live + Certolizumab pegol Contraindicated
- Bcg vaccine live + Certolizumab pegol Contraindicated
- Certolizumab pegol + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Certolizumab pegol + Measles mumps and rubella vaccine Contraindicated
- Certolizumab pegol + Measles mumps and rubella vaccine live Contraindicated
Other interactions of Ublituximab
Frequently asked questions
Can I take Certolizumab pegol with Ublituximab?
MediHelp rates the interaction as moderate. Certolizumab pegol and Ublituximab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs suppress immunity by different mechanisms, so combined use may increase the risk of serious infection. B-cell depletion from ublituximab lasts for months.
How serious is the interaction between Certolizumab pegol and Ublituximab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor closely for infection and screen for hepatitis B and tuberculosis before therapy. Avoid the combination unless clearly justified.
What other medicines interact with Certolizumab pegol?
MediHelp also lists interactions of Certolizumab pegol with, for example, Adenovirus types 4 and 7 live, Bcg intravesical live, Bcg vaccine live. The full list is on the Certolizumab pegol page.
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