Drug interactions
Cevimeline + Cimetidine
Severity: Moderate
Cevimeline and Cimetidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cevimeline is metabolized by CYP2D6 and CYP3A4, and cimetidine inhibits both enzymes. Exposure may increase, with more cholinergic effects such as sweating, nausea and diarrhea.
What this interaction means in plain words
Cevimeline and Cimetidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cevimeline belongs to Miscellaneous; Cimetidine belongs to Gastrointestinal Tract.
Why it happens
Cimetidine inhibits CYP2D6 and CYP3A4 metabolism of cevimeline.
What to do
Monitor for cholinergic adverse effects and for cardiac rhythm effects; consider famotidine as an alternative.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cimetidine
- Cimetidine + Dofetilide Contraindicated
- Cimetidine + Fezolinetant Contraindicated
- Alfentanil + Cimetidine Major
- Atazanavir + Cimetidine Major
- Carmustine + Cimetidine Major
- Cimetidine + Citalopram Major
Other interactions of Cevimeline
- Amitriptyline + Cevimeline Moderate
- Atenolol-chlorthalidone + Cevimeline Moderate
- Atenolol + Cevimeline Moderate
- Atropine + Cevimeline Moderate
- Betaxolol + Cevimeline Moderate
- Bethanechol + Cevimeline Moderate
Frequently asked questions
Can I take Cevimeline with Cimetidine?
MediHelp rates the interaction as moderate. Cevimeline and Cimetidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cevimeline is metabolized by CYP2D6 and CYP3A4, and cimetidine inhibits both enzymes. Exposure may increase, with more cholinergic effects such as sweating, nausea and diarrhea.
How serious is the interaction between Cevimeline and Cimetidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for cholinergic adverse effects and for cardiac rhythm effects; consider famotidine as an alternative.
What other medicines interact with Cimetidine?
MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Fezolinetant, Alfentanil. The full list is on the Cimetidine page.
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