Drug interactions
Cevimeline + Cyclizine
Severity: Moderate
Cevimeline and Cyclizine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cevimeline is a muscarinic agonist used for dry mouth, and cyclizine's antimuscarinic activity may reduce its effect. The anticholinergic action of cyclizine may also worsen the dryness being treated.
What this interaction means in plain words
Cevimeline and Cyclizine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cevimeline belongs to Miscellaneous; Cyclizine belongs to Respiratory.
Why it happens
Pharmacodynamic antagonism at muscarinic receptors.
What to do
Monitor for reduced salivary response and consider an alternative non-anticholinergic antiemetic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclizine
- Calcium / magnesium / potassium / sodium oxybates + Cyclizine Major
- Cyclizine + Henbane Major
- Cyclizine + Sodium oxybate Major
- Abobotulinumtoxina + Cyclizine Moderate
- Alfentanil + Cyclizine Moderate
- Alprazolam + Cyclizine Moderate
Other interactions of Cevimeline
- Amitriptyline + Cevimeline Moderate
- Atenolol-chlorthalidone + Cevimeline Moderate
- Atenolol + Cevimeline Moderate
- Atropine + Cevimeline Moderate
- Betaxolol + Cevimeline Moderate
- Bethanechol + Cevimeline Moderate
Frequently asked questions
Can I take Cevimeline with Cyclizine?
MediHelp rates the interaction as moderate. Cevimeline and Cyclizine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cevimeline is a muscarinic agonist used for dry mouth, and cyclizine's antimuscarinic activity may reduce its effect. The anticholinergic action of cyclizine may also worsen the dryness being treated.
How serious is the interaction between Cevimeline and Cyclizine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced salivary response and consider an alternative non-anticholinergic antiemetic.
What other medicines interact with Cyclizine?
MediHelp also lists interactions of Cyclizine with, for example, Calcium / magnesium / potassium / sodium oxybates, Henbane, Sodium oxybate. The full list is on the Cyclizine page.
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