Drug interactions
Cevimeline + Desipramine
Severity: Minor
Cevimeline and Desipramine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cevimeline is a muscarinic agonist used for dry mouth, and desipramine's anticholinergic effect can counteract it. Reduced benefit for xerostomia is possible, and desipramine may worsen the dry mouth being treated.
What this interaction means in plain words
Cevimeline and Desipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cevimeline belongs to Miscellaneous; Desipramine belongs to Central Nervous System.
Why it happens
Opposing muscarinic effects: cevimeline agonism versus antimuscarinic activity of desipramine; cevimeline is also CYP2D6 metabolised and desipramine is a weak CYP2D6 inhibitor.
What to do
Monitor for symptom relief of dry mouth and for cholinergic adverse effects such as sweating. Adjust therapy if benefit is lost.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Other interactions of Cevimeline
- Amitriptyline + Cevimeline Moderate
- Atenolol-chlorthalidone + Cevimeline Moderate
- Atenolol + Cevimeline Moderate
- Atropine + Cevimeline Moderate
- Betaxolol + Cevimeline Moderate
- Bethanechol + Cevimeline Moderate
Frequently asked questions
Can I take Cevimeline with Desipramine?
MediHelp rates the interaction as minor. Cevimeline and Desipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cevimeline is a muscarinic agonist used for dry mouth, and desipramine's anticholinergic effect can counteract it. Reduced benefit for xerostomia is possible, and desipramine may worsen the dry mouth being treated.
How serious is the interaction between Cevimeline and Desipramine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for symptom relief of dry mouth and for cholinergic adverse effects such as sweating. Adjust therapy if benefit is lost.
What other medicines interact with Desipramine?
MediHelp also lists interactions of Desipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Desipramine page.
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