Drug interactions
Cevimeline + Flavoxate
Severity: Moderate
Cevimeline and Flavoxate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cevimeline is a muscarinic agonist and flavoxate has antimuscarinic activity, so they may oppose each other. This may reduce the saliva-stimulating effect of cevimeline.
What this interaction means in plain words
Cevimeline and Flavoxate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cevimeline belongs to Miscellaneous; Flavoxate belongs to Genitourinary.
Why it happens
Pharmacodynamic antagonism at muscarinic receptors.
What to do
Monitor for reduced efficacy of cevimeline and worsening dry mouth. Consider an alternative to flavoxate if efficacy is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flavoxate
- Clozapine + Flavoxate Major
- Abobotulinumtoxina + Flavoxate Moderate
- Aclidinium + Flavoxate Moderate
- Amantadine + Flavoxate Moderate
- Amitriptyline + Flavoxate Moderate
- Amoxapine + Flavoxate Moderate
Other interactions of Cevimeline
- Amitriptyline + Cevimeline Moderate
- Atenolol-chlorthalidone + Cevimeline Moderate
- Atenolol + Cevimeline Moderate
- Atropine + Cevimeline Moderate
- Betaxolol + Cevimeline Moderate
- Bethanechol + Cevimeline Moderate
Frequently asked questions
Can I take Cevimeline with Flavoxate?
MediHelp rates the interaction as moderate. Cevimeline and Flavoxate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cevimeline is a muscarinic agonist and flavoxate has antimuscarinic activity, so they may oppose each other. This may reduce the saliva-stimulating effect of cevimeline.
How serious is the interaction between Cevimeline and Flavoxate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced efficacy of cevimeline and worsening dry mouth. Consider an alternative to flavoxate if efficacy is lost.
What other medicines interact with Flavoxate?
MediHelp also lists interactions of Flavoxate with, for example, Clozapine, Abobotulinumtoxina, Aclidinium. The full list is on the Flavoxate page.
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