Drug interactions
Cevimeline + Ipratropium-salbutamol
Severity: Moderate
Cevimeline and Ipratropium-salbutamol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cevimeline is a muscarinic agonist and ipratropium a muscarinic antagonist, so they oppose each other. Ipratropium may reduce the sialogogue effect of cevimeline, though systemic exposure with inhaled use is low.
What this interaction means in plain words
Cevimeline and Ipratropium-salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cevimeline belongs to Miscellaneous; Ipratropium-salbutamol belongs to Respiratory.
Why it happens
Pharmacodynamic antagonism at muscarinic receptors.
What to do
Monitor for reduced cevimeline effect on dry mouth symptoms and for cholinergic effects. Adjust therapy if efficacy is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ipratropium-salbutamol
Other interactions of Cevimeline
- Amitriptyline + Cevimeline Moderate
- Atenolol-chlorthalidone + Cevimeline Moderate
- Atenolol + Cevimeline Moderate
- Atropine + Cevimeline Moderate
- Betaxolol + Cevimeline Moderate
- Bethanechol + Cevimeline Moderate
Frequently asked questions
Can I take Cevimeline with Ipratropium-salbutamol?
MediHelp rates the interaction as moderate. Cevimeline and Ipratropium-salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cevimeline is a muscarinic agonist and ipratropium a muscarinic antagonist, so they oppose each other. Ipratropium may reduce the sialogogue effect of cevimeline, though systemic exposure with inhaled use is low.
How serious is the interaction between Cevimeline and Ipratropium-salbutamol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced cevimeline effect on dry mouth symptoms and for cholinergic effects. Adjust therapy if efficacy is lost.
What other medicines interact with Ipratropium-salbutamol?
MediHelp also lists interactions of Ipratropium-salbutamol with, for example, Amisulpride, Arsenic trioxide, Carvedilol. The full list is on the Ipratropium-salbutamol page.
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