Drug interactions
Cevimeline + Lapatinib
Severity: Minor
Cevimeline and Lapatinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cevimeline is metabolized by CYP3A4 and CYP2D6, so lapatinib may modestly increase its concentrations. This may increase cholinergic effects such as sweating, nausea and bradycardia.
What this interaction means in plain words
Cevimeline and Lapatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cevimeline belongs to Miscellaneous; Lapatinib belongs to Oncology.
Why it happens
Lapatinib weakly inhibits CYP3A4, reducing cevimeline metabolism.
What to do
Monitor for cholinergic adverse effects, including heart rate. Reduce the cevimeline dose if they become troublesome.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Other interactions of Cevimeline
- Amitriptyline + Cevimeline Moderate
- Atenolol-chlorthalidone + Cevimeline Moderate
- Atenolol + Cevimeline Moderate
- Atropine + Cevimeline Moderate
- Betaxolol + Cevimeline Moderate
- Bethanechol + Cevimeline Moderate
Frequently asked questions
Can I take Cevimeline with Lapatinib?
MediHelp rates the interaction as minor. Cevimeline and Lapatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cevimeline is metabolized by CYP3A4 and CYP2D6, so lapatinib may modestly increase its concentrations. This may increase cholinergic effects such as sweating, nausea and bradycardia.
How serious is the interaction between Cevimeline and Lapatinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for cholinergic adverse effects, including heart rate. Reduce the cevimeline dose if they become troublesome.
What other medicines interact with Lapatinib?
MediHelp also lists interactions of Lapatinib with, for example, Dofetilide, Ibutilide, Pimozide. The full list is on the Lapatinib page.
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