Drug interactions
Cevimeline + Maprotiline
Severity: Moderate
Cevimeline and Maprotiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cevimeline is a muscarinic agonist while maprotiline has anticholinergic properties, so the two may oppose each other and reduce the salivary stimulation that cevimeline is given for. Maprotiline may also add to cardiovascular effects, and the net clinical result is unpredictable.
What this interaction means in plain words
Cevimeline and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cevimeline belongs to Miscellaneous; Maprotiline belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism between muscarinic agonism and the antimuscarinic activity of the tricyclic-like antidepressant.
What to do
Monitor for reduced cevimeline efficacy and for cardiac effects such as conduction disturbances or bradycardia. Consider an antidepressant with weaker anticholinergic activity if the response to cevimeline is poor.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Other interactions of Cevimeline
- Amitriptyline + Cevimeline Moderate
- Atenolol-chlorthalidone + Cevimeline Moderate
- Atenolol + Cevimeline Moderate
- Atropine + Cevimeline Moderate
- Betaxolol + Cevimeline Moderate
- Bethanechol + Cevimeline Moderate
Frequently asked questions
Can I take Cevimeline with Maprotiline?
MediHelp rates the interaction as moderate. Cevimeline and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cevimeline is a muscarinic agonist while maprotiline has anticholinergic properties, so the two may oppose each other and reduce the salivary stimulation that cevimeline is given for. Maprotiline may also add to cardiovascular effects, and the net clinical result is unpredictable.
How serious is the interaction between Cevimeline and Maprotiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced cevimeline efficacy and for cardiac effects such as conduction disturbances or bradycardia. Consider an antidepressant with weaker anticholinergic activity if the response to cevimeline is poor.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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