Drug interactions
Cevimeline + Memantine-donepezil
Severity: Moderate
Cevimeline and Memantine-donepezil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cevimeline is a muscarinic agonist and donepezil potentiates acetylcholine, so combined use may increase cholinergic adverse effects such as sweating, nausea, diarrhea, bradycardia and bronchoconstriction.
What this interaction means in plain words
Cevimeline and Memantine-donepezil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cevimeline belongs to Miscellaneous; Memantine-donepezil belongs to Central Nervous System.
Why it happens
Additive cholinergic effects from a direct muscarinic agonist and a cholinesterase inhibitor.
What to do
Monitor heart rate and for cholinergic adverse effects, and reduce the cevimeline dose if they occur. Use particular care in patients with asthma or conduction disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cevimeline and Memantine-donepezil, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Memantine-donepezil
- Dronedarone + Memantine-donepezil Contraindicated
- Memantine-donepezil + Thioridazine Contraindicated
- Amantadine + Memantine-donepezil Major
- Amiodarone + Memantine-donepezil Major
- Amisulpride + Memantine-donepezil Major
- Amitriptyline + Memantine-donepezil Major
Other interactions of Cevimeline
- Amitriptyline + Cevimeline Moderate
- Atenolol-chlorthalidone + Cevimeline Moderate
- Atenolol + Cevimeline Moderate
- Atropine + Cevimeline Moderate
- Betaxolol + Cevimeline Moderate
- Bethanechol + Cevimeline Moderate
Frequently asked questions
Can I take Cevimeline with Memantine-donepezil?
MediHelp rates the interaction as moderate. Cevimeline and Memantine-donepezil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cevimeline is a muscarinic agonist and donepezil potentiates acetylcholine, so combined use may increase cholinergic adverse effects such as sweating, nausea, diarrhea, bradycardia and bronchoconstriction.
How serious is the interaction between Cevimeline and Memantine-donepezil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and for cholinergic adverse effects, and reduce the cevimeline dose if they occur. Use particular care in patients with asthma or conduction disease.
What other medicines interact with Memantine-donepezil?
MediHelp also lists interactions of Memantine-donepezil with, for example, Dronedarone, Thioridazine, Amantadine. The full list is on the Memantine-donepezil page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
