Drug interactions
Cevimeline + Tiotropium
Severity: Moderate
Cevimeline and Tiotropium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cevimeline is a muscarinic agonist used for dry mouth and opposes the antimuscarinic action of tiotropium. Tiotropium may worsen dry mouth and reduce cevimeline's benefit, while cevimeline may reduce bronchodilation or cause bronchoconstriction.
What this interaction means in plain words
Cevimeline and Tiotropium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cevimeline belongs to Miscellaneous; Tiotropium belongs to Respiratory.
Why it happens
Opposing actions at muscarinic receptors.
What to do
Monitor for reduced effect of either drug and for respiratory symptoms in patients with asthma or COPD. Reassess the need for both drugs if control is poor.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tiotropium
Other interactions of Cevimeline
- Amitriptyline + Cevimeline Moderate
- Atenolol-chlorthalidone + Cevimeline Moderate
- Atenolol + Cevimeline Moderate
- Atropine + Cevimeline Moderate
- Betaxolol + Cevimeline Moderate
- Bethanechol + Cevimeline Moderate
Frequently asked questions
Can I take Cevimeline with Tiotropium?
MediHelp rates the interaction as moderate. Cevimeline and Tiotropium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cevimeline is a muscarinic agonist used for dry mouth and opposes the antimuscarinic action of tiotropium. Tiotropium may worsen dry mouth and reduce cevimeline's benefit, while cevimeline may reduce bronchodilation or cause bronchoconstriction.
How serious is the interaction between Cevimeline and Tiotropium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced effect of either drug and for respiratory symptoms in patients with asthma or COPD. Reassess the need for both drugs if control is poor.
What other medicines interact with Tiotropium?
MediHelp also lists interactions of Tiotropium with, for example, Glycopyrrolate inhaled, Indacaterol-glycopyrronium, Revefenacin. The full list is on the Tiotropium page.
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