Drug interactions
Cevimeline + Verapamil
Severity: Moderate
Cevimeline and Verapamil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Verapamil may raise cevimeline levels, increasing cholinergic effects such as sweating, nausea and bradycardia. Cevimeline may also have additive conduction effects with calcium channel blockers.
What this interaction means in plain words
Cevimeline and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cevimeline belongs to Miscellaneous; Verapamil belongs to Cardiovascular.
Why it happens
CYP3A4 inhibition by verapamil reduces cevimeline metabolism; additive effects on cardiac conduction are possible.
What to do
Monitor heart rate and cholinergic adverse effects, and reduce the cevimeline dose if they occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Other interactions of Cevimeline
- Amitriptyline + Cevimeline Moderate
- Atenolol-chlorthalidone + Cevimeline Moderate
- Atenolol + Cevimeline Moderate
- Atropine + Cevimeline Moderate
- Betaxolol + Cevimeline Moderate
- Bethanechol + Cevimeline Moderate
Frequently asked questions
Can I take Cevimeline with Verapamil?
MediHelp rates the interaction as moderate. Cevimeline and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Verapamil may raise cevimeline levels, increasing cholinergic effects such as sweating, nausea and bradycardia. Cevimeline may also have additive conduction effects with calcium channel blockers.
How serious is the interaction between Cevimeline and Verapamil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and cholinergic adverse effects, and reduce the cevimeline dose if they occur.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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